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Kifunensine  - FR 900494

CAS 109944-15-2

C8H12N2O6  MW 232.19

Purity: 99%

Soluble in water and DMSO

Ordering Information:

Cat. No. Axon 1730       Prime Source

Qty1: 2 mg / €120  $156

Qty2: on request

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Biological Activity:   A potent class I α-mannosidase inhibitor that inhibits the glycoprotein biosynthesis; inhibits both human endoplasmic reticulum α-mannosidase I and Golgi class I mannosidase with Ki value of 130 and 23 nM respectively.   References:   H Kayakiri et al. Structure of kifunensine, a new immunomodulator isolated from an actinomycete. J. Org. Chem. 1989, 54(17), 4015-4016. [online]   AD Elbein et al. Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J. Biol. Chem. 1990, 265(26), 15599-15605. [online]   KW Hering et al. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum alpha-mannosidase I. J Org Chem. 2005, 70(24), 9892-9904. [online]     Chemical Name: (+)-(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione

Kifunensine | α-Mannosidase inhibitor | Axon Medchem | Axon 1730 | FR900494

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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