D-106669 | PI3K inhibitor | Axon Medchem | Axon 1719

	Chemistry Service Platform - CRO in Medicinal Chemistry × close
Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

D-106669

CAS 938444-93-0

C17H18N6O MW 322.36

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1719 Prime Source

Qty1: 2 mg (research sample) / 99 $129

Qty2: 5 mg (research sample) / 145 $189

Qty3: 25 mg (research sample) / 580 $754

Qty4: on request contract research synthesis

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Highly potent and selective PI3K inhibitor, selectively inhibiting class I PI3K (PI3Kα IC50 <10 nM, >3 log selectivity against tyrosine or serine/threonine kinases, except ERK1 and 2) and showed some activity in A549 (lung cancer) xenografts mouse model at oral dose of 30 mg/kg twice daily.

References:

SM Maira et al. Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Med. Chem. 2009, 1(1), 137-155. [online]

Chemical Name: 1-Ethyl-3-(3-(p-tolylamino)-3,4-dihydropyrido[2,3-b]pyrazin-6-yl)urea

D-106669 | PI3K inhibitor | Axon Medchem | Axon 1719 | D106669