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Tivozanib - AV 951 - KRN 951

CAS 475108-18-0

C22H19ClN4O5 MW 454.86

Purity: 99%

Soluble in DMSO to 10 mM 

Ordering Information:

Cat. No. Axon 1717        

Qty1: 5 mg (research sample) / €105  $137

Promotion: 2 x 5 mg / €160  $208 

Qty2: 25 mg (research sample) / €355  $461

Promotion: 2 x 25 mg / €520  $676 

Qty3: on request contract research synthesis

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Biological Activity:   A highly potent and orally available tyrosine kinase inhibitor (TKI), targeting VEGFR-1, 2 and 3, c-KIT and PDGFR (IC50: 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively).   References:   K Nakamura et al. KRN951, a Highly Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Has Antitumor Activities and Affects Functional Vascular Properties. Cancer Res. 2006, 66(18), 9134-9142. [online]   Eri Taguchi et al. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci. 2008, 99(3), 623. [online] C Campas et al. Tivozanib. Drugs Fut. 2009, 34(10), 793. [online]   Chemical Name: 1-(2-chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-3-(5-methylisoxazol-3-yl)urea

Tivozanib - AV 951 - KRN 951 | VEGFR inhibitor | Axon Medchem | Axon 1717 | AV951 - KRN951

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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