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(R)-(+)-SLV 319

R-SLV319

CAS 656627-66-0

C23H20Cl2N4O2S  MW 487.40 

Purity: 99% (optically pure)

Soluble in DMSO to 53 mM

Ordering Information:

Cat. No. Axon 1714   Prime Source

Qty1: 2 mg (research sample) / €95  $124

Qty2: 5 mg (research sample) / €155  $202

Qty4: on request

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Biological Activity:   Less active (ca 100-fold) enantiomer of SLV 319 (Axon 1713) that is a potent and selective CB1 receptor antagonist.   References:   JH Lange etal. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J. Med.l Chem. 2004, 47(3), 627–643. [online]   JH Lange and CG Kruse. Recent advances in CB1 cannabinoid receptor antagonists. Curr. Opin. Drug Discov. Devel. 2004, 7(4), 498-506. [online] AB Need et al. The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats. Psychopharmacol. 2006, 184(1), 26–35. [online]     Chemical Name: (R)-(+)-3-(4-chlorophenyl)-N'-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide

(R)-(+)-SLV 319 | CB1 antagonist | Axon Medchem | Axon 1714 | R-SLV319

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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