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SLV 319 - Ibipinabant

(S)-(-)-SLV319

CAS 464213-10-3

C23H20Cl2N4O2S  MW 487.40 

Purity: 99% (optically pure)

Soluble in DMSO to 53 mM

Ordering Information:

Cat. No. Axon 1713   Prime Source Promotion

Qty1: 2 mg (research sample) / €105  $137

Qty2: 5 mg (research sample) / €205  $267

Qty4: on request

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Biological Activity:   Potent and highly selective CB1 antagonist (Ki= 7.8 and 7943 nM for CB1 and peripheral cannabinoid CB2, respectively); more potent (100-fold) S-(-)-enantiomer in comparison with opposite R(+)-SLV319 (Axon 1714) .   References:   JH Lange etal. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J. Med.l Chem. 2004, 47(3), 627–643. [online]   JH Lange and CG Kruse. Recent advances in CB1 cannabinoid receptor antagonists. Curr. Opin. Drug Discov. Devel. 2004, 7(4), 498-506. [online] AB Need et al. The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats. Psychopharmacol. 2006, 184(1), 26–35. [online]     Chemical Name: (S)-(-)-3-(4-chlorophenyl)-N'-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide

SLV 319 - Ibipinabant | CB1 antagonist | Axon Medchem | Axon 1713 | (S)-(-)-SLV319

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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