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REP 3123 dihydrochloride

CAS 1013915-99-5 

1013915-71-3 (parent)

C19H19Br2N3O2S  MW 586.17

Purity: 99% (optically pure)

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1705    Prime Source Promotion

Qty1: 10 mg (research sample) / €135  $176

Qty2: 50 mg (research sample) / €485  $631

Qty3: on request

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Biological Activity:   Selective inhibitor of methionyl-tRNA synthetase (MetRS); agent to treat Clostridium difficile infection (CDI); Antibiotic.    References:   UA Ochsner et al. Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model. J. Antimicrob. Chemother. 2009, 63(5), 964-971. [online] IA Critchley et al. Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections. J. Antimicrob. Chemother. 2009, 63(5), 954-963. [online]   DM Citron et al. Comparative in vitro activity of REP3123 against Clostridium difficile and other anaerobic intestinal bacteria. J. Antimicrob. Chemother. 2009, 63(5), 972-976. [online]     Chemical Name: (R)-(+)-5-(3-(6,8-dibromochroman-4-ylamino)propylamino)thieno[3,2-b]pyridin-7(4H)-one hydrochloride

REP 3123 | MetRS inhibitor | Axon Medchem | Axon 1705 | REP3123

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