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VU 0357017 hydrochloride

CAS 1135242-13-5

C18H27N3O3.HCl  MW 369.89

Purity: 100%

Soluble in H2O and DMSO

Ordering Information:

Cat. No. Axon 1703   Prime Source

Qty1: 10 mg / €115  $150

Qty2: 50 mg / €415  $540 

Qty3: on request

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Biological Activity:   Hilghly selective positive allosteric modulator (PAM) of M1 muscarinic acetylcholine receptor (mAChR).   References:   EP Lebois, et al. Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M1 Receptor Function in the Central Nervous System. ACS Chem. Neurosci. 2010, 1(2), 104–121. [online]   TM Bridges et al. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg. Med. Chem. Lett. 2010, 20(2), 1972-1975. [online]     Chemical Name: Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride

VU 0357017 | M1 PAM | Axon Medchem | Axon 1703 | VU0357017 - VU 357017 - VU357017

Axon LigandsTM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

VU 0238429 | M5 PAM

VU 0255035 | M1 antagonist