Temsirolimus | mTOR inhibitor | Axon Medchem | Axon 1699

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Temsirolimus - CCI-779 - Torisel

CAS 162635-04-3

C56H87NO16 MW 1030.29

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1699 Prime Source

Qty1: 10 mg (research sample) / 135 $176

Qty2: 50 mg (research sample) / 450 $585

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Specific mTOR inhibitor; a signaling protein that regulates cell growth and angiogenesis; a therapeutic for the treatment of advanced renal cell carcinoma (RCC), kidney cancer and other cancer types.

References: online 1 2

X Wan et al. CCI-779 Inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/HIF-1alpha/VEGF signaling. Neoplasia 2006, 8(5), 394401. [online]

D DelBufalo et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. 2006, 66(11), 55495554. [online]

GV Thomas et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nature Medicine 2006, 12(1), 122127. [online]

Chemical Name:

Temsirolimus | mTOR inhibitor | Axon Medchem | Axon 1699 | CCI-779 - CCI779 - Torisel