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A 770041

CAS 869748-10-7

C34H39N9O3  MW 621.73

Purity: 99%

Soluble in DMSO to 100 mM

Soluble in 1 eq aq HCl to 28mM

Ordering Information:

Cat. No. Axon 1698     Prime Source

Qty1: 5 mg (research sample) / €135  $176

Promotion: 2 x 5 mg @  €200   $260

Qty2: 25 mg (research smaple) / €505  $657

Promotion: 2 x 25 mg @  €760   $988

Qty3: on request

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or by fax to: +31-50-3600390.

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Biological Activity:   Selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.   References:   RF Stachlewitz et al. A-770041, a Novel and Selective Small-Molecule Inhibitor of Lck, Prevents Heart Allograft Rejection. J. Pharmacol. Exp. Ther. 2005, 315(1), 36-41. [online]         Chemical Name: N-(4-(1-((1r,4r)-4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

A 770041 | Lck inhibitor | Axon Medchem | Axon 1698 | A770041

About LcK

Lck, one of eight members of the Src family of tyrosine kinases, is activated after T cell stimulation and is required for T-cell proliferation and interleukin (IL)-2 production.