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FR 180204

CAS 865362-74-9

C18H13N7 MW 327.34

Purity: 99%

Soluble in DMSO to 82 mM

Ordering Information:

Cat. No. Axon 1694    Prime Source

Qty1: 5 mg / €105  $137

Qty2: 10 mg / €150  $195

Qty3: 50 mg / €600  $780

Qty4: on request

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Biological Activity:   Selective, cell permeable and ATP-competitive ERK inhiitor; 30-fold selective on ERK over p38α MAPK; FR180204 was shown to inhibit ERK1 (Ki=0.31μM), ERK2 (Ki=0.14 μM) and TGFβ-induced AP-1 activation.   References:   M Ohori et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005, 336(1), 357-363. [online]   M Ohori. ERK inhibitors as a potential new therapy for rheumatoid arthritis. Drug News Perspect. 2008, 21(5), 245-250. [online]   Chemical Name: 3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-7H-pyrazolo[3,4-c]pyridazin-5-amine

FR 180204 | ERK inhibitor | Axon Medchem | Axon 1694 | FR180204

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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