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Biological Activity:
Potent, reversible, ATP-competitive and selective inhibitor of glycogen synthase kinase GSK-3 (IC50: 5 nM); Inhibition of GSK by BIO results in the activation of the Wnt signaling pathway and sustained pluripotency in human and murine embryonic stem cells (ESCs). BIO is shown to maintain self-renewal in human and murine ESCs.
References:
N Sato et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Med. 2004, 10(1), 55-63. [online]
L Meijer et al. GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem. Biol. 2003, 10, 1255-1266. [online]
AS Tseng et al. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem. Biol. 2006, 13, 957. [online]
Chemical Name: (Z)-6'-Bromo-1H,1'H-[2,3']biindolylidene-3,2'-dione 3-oxime; or (2'Z,3'E)-6-Bromoindirubin-3'-oxime
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