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Ordering Information:

Cat. No. Axon 1692   Prime Source

Qty1: 10 mg /  €125  $163

Qty2: 50 mg /  €450  $585

Qty3: on request

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Biological Activity:   G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor; Recently, BIX-01294 and RG108 (Axon 1691) have been reported to enhance the efficiency of iPS cell generation.   References:   Y Chang et al. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat. Struct. Mol. Biol. 2009, 16 312. [online]   S Kubicek et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell. 2007, 25, 473.  [online]   Y Shi et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008, 3, 568-574. [online]   Y Shi et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell. 2008, 2(6), 525-528. [online]   Chemical Name: N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride hydrate

BIX 01294 | HMTase inhibitor | Axon Medchem | Axon 1692 | BIX01294

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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LB 42708 | FTase inhibitor

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