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RG 108

CAS 48208-26-0

C19H24N2O4  MW 334.33

Purity: 99% (optically pure)

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1691   Prime Source

Qty1: 10 mg / €99  $129

Qty2: 50 mg / €320  $416

Qty3: on request

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Biological Activity:   DNA methyltransferase (MTase) inhibitor; Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity; Demethylates and reactivates epigenetically silenced tumor suppressor genes; Recently, BIX01294 and RG108 have been reported to enhance the efficiency of induced pluripotent stem cell (iPS) generation.   References:   B Brueckner et al. Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases. Cancer Res. 2005, 65, 6305-6311. [online]   C Stresemann et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 2006, 66(5), 2794-2800. [online]   Y Shi et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008, 3, 568-574. [online]   Y Shi et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell. 2008, 2(6), 525-528. [online]   Chemical Name: (S)-2-(1,3-Dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid

RG 108 | DNA methyltransferase inhibitor | Axon Medchem | Axon 1691 | RG108

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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