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(±)-E-Homocamptothecin -  

dl-hCPT - BN 80245

CAS 186668-40-6

C21H18N2O4 MW 362.38

Purity: 99%

Soluble to warm DMSO to 18 mM

Ordering Information:

Cat. No. Axon 1687    Exclusive Promotion

Qty1: 5 mg (research sample) / €135  $176

Qty2: 25 mg (research sample) / €475  $618

Qty3: on request

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Biological Activity:   A potent topoisomerase I (Topo 1) inhibitor; Homocamptothecin (hCPT) is an E-ring modified analogue of camptothecin (CPT), with enhanced stability and potent Topo-1 mediated activity; apoptosis agent   References: L Lesueur-Ginot et al. Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties. Cancer Res. 1999, 59(12), 2939-2943. [online] O Lavergne et al. Homocamptothecins: Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues. J. Med. Chem. 1998, 41(27), 5410–5419. [online]     Chemical Name: 3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione, 5-ethyl-1,4,5,13-tetrahydro-5-hydroxy-

(+/-)-E-Homocamptothecin - dl-hCPT | Topo-1 inhibitor | Axon Medchem | Axon 1687 | BN 80245 - BN80245

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