Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

Y-27632 dihydrochloride

CAS 331752-47-7

146986-50-7 (parent)

C14H21N3O.2HCl MW 320.26  

Purity: 99 % (optically pure)

Soluble in water to 100 mM

Ordering Information:

Cat. No. Axon 1683    Prime Source

Qty1: 5 mg (research sample) / €105  $137

Qty2: 25 mg (research sample) / €355  $462

Promotion: 2 x 25 mg @  €568  $738

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for our product range and services.

Biological Activity:   Selective inhibitor of Rho-Kinase (ROCK), with IC50 values of 140-220 nM for ROCK1 and ROCK2. Y-27632 was found to increases human embryonic stem cell (hESC) survival.   References: online ref 1   T Ishizaki et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000, 57, 976-983. [online]   K Watanabe et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol. 2007, 25, 681-686. [online]   C Doe et al. Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities. J. Pharmacol. Exp. Ther. 2007, 320, 89-98. [online]   D Schaafsma et al. Rho kinase inhibitors: A novel therapeutical intervention in asthma? Eur. J. Pharmacol. 2008, 585(2-3), 398-406. [online]     Chemical Name: (R)-(+)-trans-4-(1-Aminoethyl)-N-4-pyridyl cyclohexanecarboxamide dihydrochloride

Y-27632 | ROCK inhibitor | Axon Medchem | Axon 1683 | Y27632

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com © 2011

Axon Ligands in the field:

GSK 269962A | ROCK inhibitor

Y-27632 | ROCK inhibitor