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Enzastaurin  -  LY 317615

CAS 170364-57-5

C32H29N5O2  MW 515.60

Purity: 99%

Soluble in DMSO to 36 mM

Ordering Information:

Cat. No. Axon 1682     Prime Source

Qty1: 10 mg (research sample) / €125  $163

Qty2: 50 mg (research sample) / €375  $488

Qty3: on request contract research synthesis

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Biological Activity:   Selective protein kinase C beta (PKCβ) inhibitor; Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 6, 39, 83 and 110 nM, respectively.    References:   JR Graff et al. The Protein Kinase Cβ–Selective Inhibitor, Enzastaurin (LY317615.HCl), Suppresses Signaling through the AKT Pathway, Induces Apoptosis, and Suppresses Growth of Human Colon Cancer and Glioblastoma Xenografts. Cancer Res. 2005, 65, 7462-7469. [online]    MA Rizvi et al. Enzastaurin (LY317615), a protein kinase Cβ inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Mol. Cancer Ther. 2006, 5, 1783-1789. [online]     Chemical Name: 3-(1-Methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione

Enzastaurin - LY 317615 | PKCβ Inhibitor | Axon Medchem | Axon 1682 | LY317615

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

AEB 071 | PKC inhibitor

LY 317615 | PKCβ inhibitor

LY 333531 | PKCβ inhibitor

CID 755673 | PKD inhibitor