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CYT 387 

CAS 1056634-68-4

C23H22N6O2 MW 414.46 

Purity: 99%

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1681     Prime Source 

Qty1: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €180  $234 

Qty2: 25 mg (research sample) / €375  $488

Qty3: on request

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Biological Activity:   Selective and ATP-competitive Janus Kinase JAK1/JAK2 inhibitor, with IC50 to be 11 and 18 nM for JAK1 and JAK2 respectively and far less activity againist other kinases, including JAK3 (IC50=155 nM).    References:   A Pardanan et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia 2009, 23, 1441–1445. [online]   JW Tyner et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood 2010, 115(25), 5232-5240. [online]   S Verstovsek. Therapeutic potential of JAK2 inhibitors. Hematology Am Soc Hematol Educ Program. 2009, 636-642. [online]      Chemical Name: N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide

CYT 387 | JAK 1/2 inhibitor | Axon Medchem | Axon 1681 | CYT387

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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