Momelotinib - CYT387

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1681

CAS [1056634-68-4]

MF C23H22N6O2
MW 414.46

Purity: 99%
Soluble in DMSO

Momelotinib

Description

Selective and ATP-competitive Janus Kinase JAK1/JAK2 inhibitor, with IC50 to be 11 and 18 nM for JAK1 and JAK2 respectively and far less activity against other kinases, including JAK3 (IC50=155 nM). The hydrochloride salt form, Momelotenib hydrochloride (Axon 4124) is also available.

Keywords: Momelotinib | Supplier | JAK1/2 inhibitor | CYT387 | CYT-387 | CYT 387 | CAS [1056634-68-4] | JAK-STAT Pathway | JAK | Inhibitor | Enzymes

A Pardanan et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia 2009, 23, 1441–1445.

JW Tyner et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood 2010, 115(25), 5232-5240.

S Verstovsek. Therapeutic potential of JAK2 inhibitors. Hematology Am Soc Hematol Educ Program. 2009, 636-642.

JAK1 and JAK2 inhibitor

Chemical name

N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide

Parent CAS No.

[1056634-68-4]

Order

Size	Unit Price	Stock
5 mg	€80.00	In Stock
25 mg	€240.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€120.00	In Stock
2 x 25 mg	€360.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1338	CP 690550	JAK3 inhibitor	€60.00
1378	AG 490	JAK2 inhibitor	€65.00
1588	TG 101348	JAK2 inhibitor	€80.00
1598	Ruxolitinib	JAK1 and JAK2 inhibitor	€65.00
1778	AZ 960	JAK2 inhibitor	€95.00
1843	JAK2 inhibitor 13	JAK2 inhibitor	€110.00
1955	Baricitinib	Inhibitor of JAK1 and JAK2	€70.00
1992	AS 1517499	Potent and selective STAT6 inhibitor	€130.00
2072	Tofacitinib citrate	Potent Janus Kinase 3 (JAK3) inhibitor	€115.00
2217	PF 956980	JAK3 inhibitor; analogue of Axon 1338 and 2072	€90.00
2219	AT 9283	Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl)	€85.00
2231	XL 019	JAK2 inhibitor	€100.00
2314	Stattic	Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation	€50.00
2316	WP 1066	Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins	€95.00
2313	S3I 201	Potent, cellular STAT3 inhibitor	€90.00
2517	Napabucasin	Oral first-in-class cancer stemness inhibitor that works by targeting STAT3	€105.00
2539	Solcitinib	Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases	€90.00
2554	LY 2784544	Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F)	€95.00
2792	NVP-BSK805	Potent, selective and orally bioavailable JAK2 inhibitor	€125.00
2775	Cerdulatinib	Orally active dual Syk/JAK inhibitor	€85.00
3671	CEP-33779	Potent, selective and orally bioavailable JAK2 inhibitor	€95.00
3813	BMS-911543	Potent, selective and orally active inhibitor of JAK2	Inquire
3855	AZD-4205	Selective and ATP-competitive inhibitor of JAK1	Inquire
3950	Peficitinib	Potent and orally bioavailable JAK inhibitor	€120.00
3997	ASN-002	Potent dual inhibitor of SYK and pan-JAK kinases	Inquire
4006	GLPG-0634	The first orally-available, selective inhibitor of JAK1	Inquire
4124	Momelotinib hydrochloride	JAK1 and JAK2 inhibitor	€120.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

Momelotinib - CYT387

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Momelotinib - CYT387

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us