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Regorafenib  -  BAY 73-4506

CAS 755037-03-7

C21H15ClF4N4O3  MW 482.82 

Purity: 99%

Soluble in DMSO to 100 mM 

Ordering Information:

Cat. No. Axon 1678   Prime Source

Qty1: 5 mg (research sample) / €115  $150

Qty2: 10 mg (research sample) / €160  $208

Qty3: 50 mg (research sample) / €640  $832

Qty4: on request

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Biological Activity:   an oral multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinases (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.   References: online   SM Wilhelm et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int. J. Cancer. 2011, 129(1), 245-55. [online]     Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide   Regorafenib - BAY 73-4506 | Multikinase inhibitor | Axon Medchem | Axon 1678 | BAY73-9006 - BAY 734506 - BAY734506

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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