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BXL 628 - Elocalcitol

RO 26-9228

 

 

CAS 199798-84-0

C29H43FO2  MW 442.65

Purity: 99%

Soluble in DMSO

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1676    Exclusive Promotion

 

Qty1: 2 mg (research sample) / €165  $215

Qty2: 5 mg (research sample) / €365  $475

Qty3: 25 mg (research sample) / inquire

 

Qty4: on request

 

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Biological Activity:

 

A vitamin D3 analog having agonistic activities at vitamin D receptor (VDR); BXL-628 inhibits prostate cell growth and RhoA/Rho-kinase signaling, a calcium sensitizing pathway; having anti-proliferative and anti-inflammatory properties in benign prostatic hyperplasia (BPH) treatment.

 

References:

 

C Crescioli et al. Inhibition of prostate cell growth by BXL-628, a calcitriol analogue selected for a phase II clinical trial in patients with benign prostate hyperplasia. Eur. J. Endocrinol. 2004, 150(4), 591-603. [online]

 

E Colli et al. BXL628, a novel vitamin D3 analog arrests prostate growth in patients with benign prostatic hyperplasia: a randomized clinical trial. Eur Urol. 2006, 49(1), 82-86. [online]

 

A Morelli et al. BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder. Prostate. 2007, 67(3), 234-247. [online]

 

G Penna et al. The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways. Prostate. 2009, 69(5), 480-493. [online]

 

Chemical Name: (1R,5S,Z)-3-((E)-2-((3aS)-3-((S,E)-6-ethyl-6-hydroxyoct-4-en-2-yl)-3a-methyl-3a,4,5,6-tetrahydro-1H-inden-7(7aH)-ylidene)ethylidene)-5-fluoro-4-methylenecyclohexanol

 

BXL 628 - Elocalcitol | VDR agonist | Axon Medchem | Axon 1676 | BXL628

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

Nuclear Receptors - Vitamine D Receptor (VDR) (click)

 

BXL 628 | VDR agonist

Doxercalciferol | VDR agonist

 

 

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