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PD 173074

CAS 219580-11-7

C28H41N7O3  MW 523.67

Purity: 99%

Soluble in DMSO to 100 mM

and in EtOH to 100 mM 

Ordering Information:

Cat. No. Axon 1673    Prime Source

Qty1: 5 mg (research sample) / €95  $124

Promotion: 2 x 5 mg  @  €140  $182

Qty2: 25 mg (research sample) / €350  $455

Promotion: 2 x 25 mg  @  €500  $650

Qty3: on request

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Biological Activity:   Potent and selective FGFR inhibitor with IC50 to be 21.5 and 5 nM for FGFR1 and FGFR3 inhibition respectively.   References:   OE Pardo et al. The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo. Cancer Res. 2009, 69, 8645. [online]   M Miyake et al. 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest. J. Pharmacol. Exp. Ther. 2010, 332 795. [online]   L Zaragosi et al. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 2006, 24 2412-2419. [online]     Chemical Name: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

PD 173074 | FGFR inhibitor | Axon Medchem | Axon 1673 | PD173074

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

Axon Ligands In This Field:

NVP-BGJ398 | FGFR inhibitor