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PS47

CAS 1180676-33-8

C17H15ClO2 MW 286.75

Purity: 99%

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1664     

Qty1: 10 mg / €90  $117

Qty2: 50 mg / €270  $351

Qty3: on request

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Biological Activity:   Inactive E-isomer of PS48 (Axon 1659) that has a Z-configuration; hence PS47 can be used as a negative control for PS48 as an allosteric PDK1 activator.   References:   A Stroba et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J. Med. Chem. 2009, 52(15), 4683-93. [online]   V Hindie et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nature Chem. Biol. 2009, 5, 758-764. [online]             Chemical Name: (2E)-5-(4-Chloro-phenyl)-3-phenyl-2-pentenoic acid

PS47 | E-isomer of PS48 | Axon Medchem | Axon 1664 | PS 47

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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