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Perifosine

KRX 0401 - D 21266

CAS 157716-52-4

C25H52NO4P  MW 461.66

Purity: >98%

Water soluble to 47 mM

Ordering Information:

Cat. No. Axon 1663    Prime Source

Qty1:  5 mg (researchs ample) / €115  $150

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €415  $540

Promotion: 2 x 25 mg @ €620  $806

Qty3: on request contract research synthesis

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Biological Activity:   Orally available Akt inhibitor that inhibits Akt activation in the PI3K pathway.   References: online 1, 2   JJ Gills and PA Dennis. Perifosine: update on a novel Akt inhibitor. Curr. Oncol. Rep. 2009, 11(2), 102-110. [online]   SB Kondapaka et al. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Mol. Cancer Ther. 2003, 2(11), 1093-1103. [online]   V Patel et al. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res. 2002, 062(5), 1401-1409. [online]     Chemical Name: 1,1-dimethylpiperidinium-4-yl octadecyl phosphate

Perifosine | AKT inhibitor | Axon Medchem | Axon 1663 | KRX 0401 - D 21266 - KRX0401 - D21266

Axon Ligands In The Field: