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PF 02341066 - Crizotinib

PF-2341066

CAS 877399-52-5

C21H22Cl2FN5O MW 450.34

Purity: 99% (optically pure)

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1660    Prime Source

Qty1: 2 mg (research sample) / €95  $124

Qty2: 5 mg (research sample) / €135  $176

Promotion: 2 x 5 mg @ €200  $260

Qty3: 25 mg (research sample) / €475  $618

Qty4: on request contract research synthesis

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Biological Activity:   Potent, selective and ATP-competitive inhibitor of c-Met/HGF receptor and the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively.   References: online 1 2 3 4   HY Zou et al. An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms. Cancer Res. 2007, 67, 4408. [online]   SH Ou et al. Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in a Non-small Cell Lung Cancer Patient with De Novo MET Amplification. J. Thor. Oncol. 2011, 6(5), 942-946. [online]   U McDermott et al. Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors. Cancer Res. 2008, 68(9), 3389-3395. [online]     Chemical Name: (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

PF 02341066 - Crizotinib | c-MET/ALK inhibitor | Axon Medchem | Axon 1660 | PF02341066 - PF 2341066 - PF2341066

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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