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PS48

CAS 1180676-32-7 

C17H15ClO2  MW 286.75

Purity: 99%

Soluble in DMSO to 100 mM

and EtOH to 50 mM

Ordering Information:

Cat. No. Axon 1659     Prime Source Promotion

Qty1: 10 mg / €90  $117

Qty2: 50 mg / €270  $351

Qty3: on request

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Biological Activity:   Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDK1). PS48 has a Z-configuration in comparison with its E-isomer PS47 (Axon 1664).    References:   A Stroba et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J. Med. Chem. 2009, 52(15), 4683-93. [online]   V Hindie et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nature Chem. Biol. 2009, 5, 758-764. [online]

Chemical Name: (2Z)-5-(4-Chloro-phenyl)-3-phenyl-2-pentenoic acid

PS48 | Allosteric PDK1 activator | Axon Medchem | Axon 1659 | PS 48

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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