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Irestatin 9389

CAS 626221-47-4

C16H13F3N4OS2 MW 398.43

Purity: 99%

Soluble in DMSO to 78 mM

Ordering Information:

Cat. No. Axon 1656   Prime Source

Qty1: 10 mg / €125  $163

Qty2: 50 mg / €375  $488

Qty3: on request

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Biological Activity:   A potent inhibitor of the endonuclease IRE1 (IC50 = 6.3 nM) and unfolded protein response (UPR).    References:   D Feldman and AC Koong. Irestatin, a potent inhibitor of IRE1α and the unfolded protein response, is a hypoxia-selective cytotoxin and impairs tumor growth. J. Clin. Oncol. (2007 ASCO Ann. Meeting Proc. PI) 2007, 25 (18S), 3514. [online]     Chemical Name: 2-(3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-ylthio)-N-(4-methylthiazol-2-yl)acetamide

Irestatin 9389 | IRE1 inhibitor | Axon Medchem | Axon 1656

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Axon Ligands In The Field: