Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

AEE 788  -  NVP-AEE788

CAS 497839-62-0 

C27H32N6  MW 440.58

 Purity: 99% (optically pure)

Soluble in DMSO to 90 mM 

Ordering Information:

Cat. No. Axon 1653    Prime Source

Qty1: 5 mg (research smaple) / €135  $176

Promotion: 2 x 5 mg @ €200  $260

Qty2: 25 mg (research sample) / €475  $618

Promotion: 2 x 25 mg @ €660  $858

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for payment and tech support.

Biological Activity:   A dual family EGFR/ErbB2 and VEGFR kinase inhibitor with antitumor and antiangiogenic activity.   References:   P Traxier, PR Allegrini, R Brandt, et al. AEE788: A dual family EGFR/ErbB2 and VEGFR kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004, 64, 4931-4941. [online]   D Meco et al. Dual Inhibitor AEE788 Reduces Tumor Growth in Preclinical Models of Medulloblastoma. Transl. Oncol. 2010, 3(5), 326-335. [online]       Chemical Name: (R)-6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-(1-phenylethyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine

AEE 788 | EGFR/VEGFR inhibitor | Axon Medchem | Axon 1653 | NVP-AEE788

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.