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Ambrisentan

BSF 208075 - Letairis - Volibris

CAS 177036-94-1

C22H22N2O4  MW 378.42

Purity: 99% (optically pure)

Ordering Information:

Cat. No.: Axon 1648    Prime Source Promotion

Qty1: 5 mg (research sample) / €135  $176        

Qty2: 25 mg (research sample) / €435  $566 

Qty3: on request

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Biological Activity:   Orally active non-peptide endothelin-A (ETA) receptor antagonist; therapeutic agent for the treatment of pulmonary arterial hypertension.   References: online   H Vatter and V Seifert. Ambrisentan, a non-peptide endothelin receptor antagonist. Cardiovasc Drug Rev 2006, 24 (1), 63–76. [online]   CC Chong. Ambrisentan: A new, nonsulphonamide, selective endothelin receptor antagonist for the treatment of pulmonary arterial hypertension. PVRI Review 2009, 1, 31-33. [online]   H Riechers et al. Discovery and Optimization of a Novel Class of Orally Active Nonpeptidic Endothelin-A Receptor Antagonists. J. Med. Chem., 1996, 39(11), 2123–2128. [online]   Chemical name: (+)-(S)-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid

Ambrisentan | ETA antagonist | Axon Medchem | Axon 1648

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Axon Ligands in the field:

Ambrisentan | ET_A antagonist

Axon Ligands ^TM    

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.