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Biological Activity:
Potent and selective histone deacetylase 6 (HDAC6) inhibitor, with IC50 to be 2.4 nM (HDAC6) and 71 nM (HDAC1). (*2010 revised affinities)
References:
KV Butler et al. Rational Design and Simple Chemistry Yield a Superior,
Neuroprotective HDAC6 Inhibitor, Tubastatin A. J. Am. Chem. Soc. 2010, 132, 10842–10846. [online]
AP Kozikowski et al. Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6. J. Med. Chem. 2008, 51, 4370–4373. [online]
Chemical Name: tert-butyl 4-(3-(7-(hydroxyamino)-7-oxoheptylcarbamoyl)isoxazol-5-yl)phenylcarbamate
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