Biphenylindanone A - BINA | mGluR2 PAM | Axon Medchem

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Biphenylindanone A - BINA

LS-193,571

CAS 866823-73-6

C30H30O4 MW 454.56

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1644 Prime Source

Qty1: 5 mg / 95 $124

Promotion: 10 mg @ 119 $155

Qty2: 25 mg / 325 $423

Promotion: 50 mg @ 459 $597

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent and selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 2 (mGluR2)

References:

R Galici et al. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol. Exp. Ther. 2006, 318(1), 173185. [online]

MA Benneyworth et al. A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol. Pharmacol. 2007, 72(2), 477484. [online]

Chemical Name: 3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid

Biphenylindanone A - BINA | mGluR2 PAM | Axon Medchem | Axon 1644

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.