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CHIR 124

CAS 405168-58-3

C23H22ClN5O  MW 419.91

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1636    2012 Promotion 

Qty1: 2 mg (research sample) / €100  $130

Qty2: 5 mg (research sample) / €145  $189

Promotion: 2 x 5 mg @ €220  $286

Qty3: 25 mg (research sample) / €545  $709

Promotion: 2 x 25 mg @ €780  $1014

Qty4: on request

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Biological Activity:   Potent, cell permeable and selective Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).   References: AN Tse et al. CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo. Clin. Cancer Res. 2007, 13, 591-602. [abstract] [article]   Y Tao et al. Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints. Cell Cycle. 2009, 8(8), 1196-205. [online]     Chemical Name: 4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one

CHIR 124 | CHK1 inhibitor | Axon Medchem | Axon 1636 | Chir124

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

Axon Ligands in The Field:

AZD 7762 | CHK inhibitor

CHIR 124 | CHK1 inhibitor

PF 477736 | CHK1 inhibitor

MK 1775 | Wee1 inhibitor