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Remogliflozin

GSK 189074

CAS 329045-45-6

C23H34N2O7  MW 450.53

Purity: 99%

Ordering Information:

Cat. No. Axon 1634

Qty1: 5 mg / €135  $176

Qty2: 25 mg / €485  $631

Qty3: on request

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Biological Activity:   Remogliflozin inhibits the sodium-glucose transport (SGLT2) proteins, which are responsible for glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Its prodrug is Remoglifozin etabonate (GSK 189075), investigated as a treatment of anti diabetes type II.   References: online   Y Fujimori et al. Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. J. Pharmacol. Exp. Ther. 2008, 327(1), 268-276. [online]     Chemical Name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1H-pyrazol-3-yloxy)tetrahydro-2H-pyran-3,4,5-triol

Remogliflozin | SGLT2 inhibitor | Axon Medchem | Axon 1634 | GSK 189074

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Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.