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SGI 1776 free base

CAS 1025065-69-3 

C20H22F3N5O  MW 405.42

Purity: 99%

Ordering Information:

Cat. No. Axon 1633    Prime Source

Qty1: 5 mg (research sample) / €139  $181

Promotion: 2 x 5 mg @ €210  $273

Qty2: 25 mg (research sample) / €520  $676

Promotion: 2 x 25 mg @ €740  $962

Qty3: on request contract research synthesis

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Biological Activity:   A potent and selective inhibitor of Pim kinases, inducing apoptosis and cell cycle arrest, thereby causing a reduction in phospho-BAD levels and enhancement of mTOR inhibition in vitro. Most notably, SGI-1776 induced significant tumor regression in MV-4-11 (AML) and MOLM-13 (AML) xenograft models.   References: online 1 2   LS Chen et al. Pim kinase inhibitor, SGI-1776, induces apoptosis in CLL lymphocytes. Blood, 2009, 114 (19), 4150-4157. [online]   SM Mumenthaler et al. Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. Mol. Cancer Ther. 2009, 8(10), 2882-2893. [online]     Chemical Name: Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-

SGI 1776 | Pim inhibitor | Axon Medchem | Axon 1633 | SGI1776

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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