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GSK 461364 analogue II

CAS 929095-22-7

C27H27F3N4O3S  MW 544.59

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1626

Qty1:  5 mg (research sample) / €135  $176

Qty3: 25 mg (research sample) / €505  $657

Qty4: on request

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Biological Activity:   Potent Polo-like kinase (PLK) inhibitor, selective at PLK1 (IC50: 2 nM) over PLK3 (IC50: 270 nM).   References:   TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92. [online]   KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7. [online]     Chemical Name: (R)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

GSK 461364 analogue II | PLK1 inhibitor | Axon Medchem | Axon 1626 | GSK461364 analogue II

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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