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PF 573228

CAS 869288-64-2 

C22H20F3N5O3S  MW 491.49

Purity: 99%

Soluble in DMSO (>100 mM) 

Ordering Information:

Cat. No. Axon 1623    Prime Source Promotion

Qty1: 5 mg (research sample) / €95  $124

Qty2: 25 mg (research sample) / €335  $436

Qty3: on request

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Biological Activity:   Potent and selective inhibitor of focal adhesion kinase (FAK) with IC50 of 4 nM; Displays 50-250-fold selectivity over other protein kinases; a useful tool in functional study of non-receptor tyrosine inhibitor FAK in integrin-dependent signaling pathways in normal and cancer cells.   References:   ML Jones et al. Characterization of a novel focal adhesion kinase inhibitor in human platelets. Biochem Biophys Res Commun. 2009, 389(1), 198-203. [online]   JK Slack-Davis et al. Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor. J. Biol. Chem, 2007, 282, 14845-14852. [online]     Chemical Name: 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

PF 573228 | FAK Inhibitor | Axon Medchem | Axon 1623 | PF573228 - PF-228

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

Axon Ligands in The Field:

PF 573228 | FAK inhibitor

Best quality PF 573228 from Axon Medchem for generating reliable and reproducibe biological data.