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NVP-LDE225  -  LDE 225

CAS 956697-53-3

C26H26F3N3O3  MW 485.50

Purity: 99%

Ordering Information:

Cat. No. Axon 1619       Prime Source

Qty1: 5 mg (research sample) / €130  $169

Promotion: 2 x 5 mg @ €190  $247

Qty2: 25 mg (research sample) / €450  $585

Promotion: 2 x 25 mg @ €650  $845

Qty3: on request contract research synthesis

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Biological Activity:   Potent, selective and orally bioavailable Smoothened (SMO) antagonist (IC50: 50 nM); it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).   References:   S Pan et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134. [online]       Chemical Name: N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4′-(trifluoromethoxy)biphenyl-3-carboxamide

NVP-LDE225 | SMO antagonist | Axon Medchem | Axon 1619 | LDE 225

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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