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HMR 1031

CAS 479203-71-9 

C35H41N5O6 MW 627.73 

 Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1616    Exclusive Promotion

Qty1: 2 mg (research sample) / €105  $137

Qty2: 5 mg (research sample) / €165  $215

Qty3: 25 mg (research sample) / €660  $858

Qty4: on request contract research synthesis

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Biological Activity:   Potent and specific intrigen α4β1 or very late antigen 4 (VLA-4) receptor antagonist binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin; HMR1031 is a potential inhaled drug for the treatment of asthma.   References:   B Shah et al. Effect of food on pharmacokinetics of an inhaled drug: a case study with a VLA-4 antagonist, HMR1031. J. Clin. Pharmacol. 2003, 43(12), 1341-9. [online]   S Rohatagi et al. Pharmacoscintigraphic comparison of HMR 1031, a VLA-4 antagonist, in healthy volunteers following delivery via a nebulizer and a dry powder inhaler. Am. J. Ther. 2004, 11(2), 103-113. [online]   Z Diamant et al. Effect of a very late antigen-4 receptor antagonist on allergen-induced airway responses and inflammation in asthma. Clin. Exp. Allergy 2005, 35(8), 1080–1087. [online]     Chemical Name: (3S)-3-(((2S)-2-(4,4-dimethyl-3-(4-((((2-methylphenyl)amino)carbonyl)amino)benzyl)-2,5-dioxoimidazolidin-1-yl)-4-methylpentanoyl)amino)-3-phenylpropanoic acid

HMR 1031 | VLA-4 antagonist | Axon Medchem | Axon 1616 | HMR1031

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Axon Ligands In The Field:

HMR 1031 | VLA-4 antagonist