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KRP 203 

CAS 509088-69-1

C24H26ClNO3S.HCl  MW 480.45

Purity: >98%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1615  

Qty1: 5 mg (research sample) / €145  $189

Qty2: 25 mg (research sample) / €505  $657

Qty3: on request contract research synthesis

Send enquiry to: order@axonmedchem.com

This item is suspended due to the request of developer!

Biological Activity:   Potent and selevtive sphingosine-1-phosphate (S1P) receptor 1 agonist (ED50 in the nM range); immunosuppressant.   References:   M Takahashi et al. A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts. Transplantation Proceedings 2005, 37(1), 143-145.   T Kaneko etal. Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice. Biochem. Biophys. Res. Commu. 2006, 345(1), 85-92.   J Song et al. A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-deficient mice. J. Pharmacol. Exp. Ther. 2008, 324(1), 276-283.     Chemical Name: 2-amino-2-(4-(3-(benzyloxy)phenylthio)-2-chlorophenethyl)propane-1,3-diol hydrochloride

KRP 203 | S1P1 agonist | Axon Medchem | Axon 1615 | KRP203

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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