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MDV 3100

CAS 915087-33-1 

C21H16F4N4O2S  MW 464.44

Purity: >98%

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1613     Prime Source

Qty1: 5 mg (research sample) / €135  $176

Promotion: 2 x 5 mg @ €200  $260

Qty2: 25 mg (research sample) / €475  $618

Promotion: 2 x 25 mg @ €700  $910

Qty3: on request contract research synthesis

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Biological Activity:   An orally active and very potent antagonist of androgen receptor (AR); Second-generation of antiandrogen for the treatment of advanced prostate cancer; highly recommended tool in AR research.   References: online   C Tran et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009, 324 (5928), 787-790. [online]   C Harrison. Anticancer drugs: New approaches to anti-androgen activities. Nature Reviews Drug Discovery 2009, 8, 452-453. [online]   CJ Hoimes and WK Kelley. Redefining hormone resistance in prostate cancer. Ther Adv Med Oncol. 2010, 2(2), 107–123. [online]   G Di Lorenzo et al. Castration-resistant prostate cancer: current and emerging treatment strategies. Drugs 2010, 70(8), 983-1000.   N Sharifi. New agents and strategies for the hormonal treatment of castration-resistant prostate cancer. Exp. Opin. Invest. Drugs 2010, 19(7), 837-846.   HI Scher et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet 2010, 375(9724), 1437-1446.   Y Chen et al. Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target. Lancet Oncol. 2009, 10(10), 981-991.     Chemical Name: 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-Benzamide

MDV 3100 | Antiandrogen | Axon Medchem | Axon 1613 | MDV3100

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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