LY 334370 | 5-HT1F agonist | Axon Medchem | Axon 1612

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LY 334370 hydrochloride

CAS 199673-74-0 (HCl)

182663-08-2 (free base)

C21H22FN3O.HCl MW 387.88

Purity: 99%

Soluble in Water and DMSO

Ordering Information:

Cat. No. Axon 1612 Prime Source

Qty1: 10 mg / 115 $150

Promotion: 2 x 10 mg @ 160 $208

Qty2: 50 mg / 450 $585

Promotion: 2 x 50 mg @ 660 $858

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Selective 5-HT1F receptor agonist with Ki value to be 1.87 nM.

References: online

DS Dupuis et al. G-protein activation at 5-HT1A receptors by the 5-HT1F ligand LY-334,370 in guinea-pig brain sections and recombinant cell lines. Br. J. Pharmacol. 1998, 124(2), 28390.

S Shepheard et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY-334,370. Cephalalgia 1999, 19(10), 851-858.

DJ Goldstein et al. Selective seratonin 1F (5-HT1F) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet 2001, 358 (9289), 1230-1234.

Chemical Name: 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride

LY 334370 | 5-HT1F agonist | Axon Medchem | Axon 1612 | LY334370

Axon Ligands^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.