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FK 960

CAS 133920-70-4

C13H16FN3O2  MW 265.28

Purity: 99%

Ordering Information:

Cat. No.: Axon 1607    Prime Source  

Qty1: 10 mg (research sample) / €120  $156

Qty2: 50 mg (research sample) / €280  $364

Qty4: on request

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Biological Activity:   Somatostatin receptor agonist and also a 5-HT agonist; FK960 stimulates both serotonin and somatostatin production as a cognitive enhancer. However, its development for Alzheimer's disease (AD) was terminated in 2003.   References:   A Graul et al. FK-960, Congnition Enhancer. Drug. Fut. 1997, 22(8), 830-832.    N Matsuoka and TG Ainer. FK960 [N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate], a Novel Potential Antidementia Drug, Improves Visual Recognition Memory in Rhesus Monkeys: Comparison with Physostigmine. J. Pharmacol. Exp. Ther. 1997, 280(3), 1201-1209. [online]   JP Hodgkiss and JS Kelly. Effect of FK960, a Putative Cognitive Enhancer, on Synaptic Transmission in CA1 Neurons of Rat Hippocampus. J. Pharmacol. Exp. Ther. 2001, 297(2), 620-628. [online]   F Wang et al. Modulation of Ca2+Channel Currents by a Novel Antidementia Drug N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960) in Rat Hippocampal Neurons. J. Pharmacol. Exp. Ther. 2004, 308 (1), 120-126. [online]   Chemical name: N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate

FK 960 | Somatostatin agonist | Axon Medchem | Axon 1607 | FK960

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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