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Biological Activity:
A potent and subtype selective GABAA receptor partial agonist potentially useful in treating generalized anxiety disorder; the Mdr1 P-glycoprotein (P-gp) substrate.
References:
CL Shaffer et al. Metabolism and disposition of a g-aminobutyric acid type A receptor partial agonist in humans. Drug Metab. Disp. (2008), 36(4), 655-662.
K Venkatakrishnan et al. Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures. Drug Metab. Disp. (2007), 35(8), 1341-1349
Chemical Name: N-[3-fluoro-4-[2-(propylamino)ethoxy]phenyl]-4,5,6,7-tetrahydro-4-oxo-1H-indole-3-carboxamide mesylate
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