Rolofylline - KW3902

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1603

CAS [136199-02-5]

MF C20H28N4O2
MW 356.46

Purity: 99%
Soluble in DMSO

Rolofylline

Description

Potent and selective adenosine A1 receptor antagonist, with Ki values to be 0.19 nM and 170 nM for A1 and A2 receptors respectively

H Nonaka et al. KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br J Pharmacol. 1996, 117(8), 1645–1652.

MM Givertz et al. The effects of KW-3902, an adenosine A1-receptor antagonist, on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance. J. Am. Coll. Cardiol. 2007, 50(16), 1551–60.

BM Massie et al. Rolofylline, an Adenosine A1−Receptor Antagonist, in Acute Heart Failure. N. Engl. J. Med. 2010, 363(15), 1419-28.

Cardiovascular CNS A1 A18

Adenosine A1 antagonist

Chemical name

8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione

Parent CAS No.

[136199-02-5]

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5 mg	€90.00	In Stock
25 mg	€320.00	In Stock

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Rolofylline - KW3902

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