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Biological Activity:
Highly specific and cell-permeable p70 ribosomal S6 kinase (S6K1) inhibitor with Ki of 20 nM and IC50 of 160 nM; having no effect on the closely related RSK and MSK kinases; Useful tool for delineating S6K1-specific roles downstream of mTOR.
References:
LR Pearce et al. Characterisation of PF-4708671 a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem. J. 2010, 431, 245-255. [online]
Chemical Name: 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole
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| PF 4708671 | S6K1 inhibitor | Axon Medchem | Axon 1602 | PF4708761 |
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Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.
axonmedchem.com © 2011 |
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Axon Ligands in the field:
BI-D1870 | p90 RSK inhibitor
PF 4708671 | S6K1 inhibitor
Click Here To See Featured Cell Signaling and Oncology Ligands from Axon Ligands Collection
About RSK:
Ribosomal S6 kinase (RSK) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase (S6K1). |
