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Pagoclone  - CI-1043

* (+)-enantiomer

CAS 133737-32-3

 C23H22ClN3O2  MW 407.89

Purity: 99% (optically pure)

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Cat. No. Axon 1594       Exclusive Promotion

Qty1: 5 mg (research sample) / €135  $176      

Qty2: 25 mg (research sample) / €475  $618

Qty3: on request

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Biological Activity:   Subtype selective partial agonist at GABAA receptor, which binds primarily to the α2/α3 subtypes which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the α1 subtype which produces the sedative and memory loss effects; nonbenzodiazepine anxiolytic   References: online 1   JR Atack. The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Exp. Opin. Invest. Drugs. 2005, 14(5), 601-618. DJ Nutt. Alcohol alternatives - a goal for psychopharmacology? J. Psychopharmacol. 2006, 20(3), 318–320. [online]     Chemical Name: (+)-2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one

Pagoclone | GABAA α2/α3 agonist | Axon Medchem | Axon 1594 | CI-1043

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research and synthesis.

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