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ABT 888 - Veliparib

CAS 912444-00-9

C13H16N4O MW 244.29

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1593    Prime Source

Qty1: 2 mg (research sample) /  €95  $124

Qty2: 5 mg (research sample) / €145  $189

Qty3: on request contract research synthesis

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Biological Activity:   Potent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents.     References: online 12 3   CK Donawho et al. ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models. Clin. Cancer Res. 2007, 13, 2728. [online]       Chemical Name: 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide

ABT 888 - Veliparib | PARP inhibitor | Axon Medchem | Axon 1593 | ABT888

Axon LigandsTM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands in the field:

ABT 888 | PARP inhibitor

AG 014699 | PARP inhibitor

DR 2313 | PARP inhibitor

Iniparib | PARP inhibitor

NU 1025 | PARP inhibitor

Olaparib | PARP inhibitor