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TG 101348

CAS 936091-26-8

C27H36N6O3S  MW 524.68

Purity: 99%

Ordering Information:

Cat. No. Axon 1588    Prime Source

Qty1: 5 mg (research sample) / €135  $176

Promotion: 2 x 5 mg @ €190  $247

Qty2: 25 mg (research sample) / €405  $527

Promotion: 2 x 25 mg @ €600  $780

Qty3: on request

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Biological Activity:   An orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 (JAK2, IC50: ca 3 nM) with potential antineoplastic activity.   References: online 1 2 3   J Hood et al. TG101348, a potent, highly selective JAK2 inhibitor, inhibits colony formation in stem cells from polycythemia vera patients and prevents JAK2V617F-mediated splenomegaly and death in a mouse model. J. Clin. Oncol. (2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S) 2007, 7031.   G Wernig et al. Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera. Cancer Cell 2008, 13, 311–320. [online]     Chemical Name: (N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide

TG 101348 | JAK2 inhibitor | Axon Medchem | Axon 1588 | TG101348

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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