KU 0060648 | DNA-PK inhibitor | Axon Medchem

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KU 0060648 trihydrochloride

CAS 881375-00-4

C33H34N4O4S.3HCl MW 692.10

Purity: 99%

(Water-soluble DNA-PK inhibitor)

Ordering Information:

Cat. No. Axon 1584 Exclusive Promotion

Qty1: 2 mg (research sample) / €115 $150

Qty2: 5 mg (research sample) / €175 $228

Qty3: 25 mg (research sample) / €675 $878

Qty4: on request contract research synthesis

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases.

* The HCl salt of KU-0060648 has excellent aqueous solubility.

References:

C Cano et al. Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK). RSC 2009 meeting abstract O6.

C Cano et al. Development of potent water-soluble inhibitors of the DNA-dependent protein kinase (DNA-PK). NARI cancer conference 2010 [online]

J Bardos et al. Radio- and chemosensitization through inhibition of DNA-PK by KU-0060648. Mol. Cancer Ther. 2009, 8(12 Suppl), A116. [online]

F Dumont et al. Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin. Ther. Pat. 2009, 19(6), 775-799. [online]

Chemical Name: 2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide trihydrochloride

KU 0060648 | DNA-PK inhibitor | Axon Medchem | Axon 1584 | KU0060648 - KU 60648 - KU60648