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PF 04217903 mesylate

CAS 956906-93-7 (MsOH)

956905-27-4 (parent)

C19H16N8O.CH4O3S, MW 468.49 

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1583    Prime Source

Qty1: 5 mg (research sample) /  €125  $163

Promotion: 2 x 5 mg / €180  $234

Qty2: 25 mg (research sample) /  €425  $553

Promotion: 2 x 25 mg / €620  $806

Qty3: on request

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Biological Activity:   An orally bioavailabe tyrosine kinase inhibitor, targeting MET (or c-MET); it selectively binds to and inhibits mesenchymal epithelial transition (low nM Ki values and >1000 fold selective relative to 208 kinases) with potential antineoplastic activity.   References: online   SL Timofeevski et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry. 2009, 48(23), 5339-49. [online]     Chemical Name: 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol methanesulfonate

PF 04217903 | c-MET inhibitor | Axon Medchem | Axon 1583 | PF04217903 - PF 4217903 - PF4217903

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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