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Foretinib 

GSK 1363089 - Exel 2880 - XL 880

CAS 849217-64-7
C34H34F2N4O6  MW 632.65
Purity: >98%

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Cat. No. Axon 1582    Prime Source

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Biological Activity:   An orally available inhibitor targeting c-MET (IC50: 0.4 nM), VEGFR and AXL.   References: online   JP Eder et al. A Phase I Dose-Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Early Antitumor Activity of Foretinib. Clin. Cancer Res. 2010, 16(13), 3507. [online]   L Liu et al. Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res. 2009, 69(17), 6871-8. [online]     Chemical Name: N-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Foretinib | MET/VEGFR2 inhibitor | Axon Medchem | Axon 1582 | GSK 1363089 - Exel 2880 - XL 880 - XL880

Axon Ligands ^TM  - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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